A new article from the research unit in Chemical Sciences

Girard E., Lopes P., Spoerner M., Dhaussy A.C., Prangé T., Kalbitzer H. R., Colloc’h N.

Chemical Science, in press

‘Equilibria between conformational states of the Ras oncogene protein revealed by high pressure crystallography’DOI. https://doi.org/10.1039/D1SC05488K

Using high pressure macromolecular crystallography enable us to characterize with a high precision the excited sub-states of Ras protein involved in many cancers. Pressurizing Ras crystal has induced a phase transition with the crystal. Above the pressure of transition, we have mapped out the different segments of Ras which undergo structural changes, adopting high-energy conformations corresponding to transient intermediate states.