Brain MATRiX (2021-2025)
« Matrix Therapy against Radiotherapy-Induced Brain damage and Cognitive deficits »
Although radiotherapy (RT), used alone or in combination with other treatments, is a standard treatment for primary brain tumors or brain metastases, it often induces severe cognitive deficits. In order to improve the efficiency of brain RT while preserving the quality of life of patients, the precise mechanisms underlying RT-induced deleterious effects must be identified and it also seems necessary to propose new treatments, which associated with RT would protect the brain from radiation-induced damage.
The “Brain-MATRiX” aims to better understand the key mechanisms of cognitive deficits induced by brain RT and limits them by a new therapy that targets the extracellular matrix (ECM), an essential structure for tissue cohesion. Indeed, it has been shown that the ECM is damaged by RT. The proposed therapy aims at using an agent mimicking a component of ECM. To meet these 2 objectives, this project will be carried out on a preclinical scale on different in vitro and in vivo experimental models and will use a range of complementary techniques such as MRI imaging, behavioral tests, immunohistological and biochemical studies which will provide insights from molecular to functional levels.
Partners : ISTCT (Caen, FR), Gly-CRRET, (Créteil, FR) OTR3 S.A.S (Paris, FR)
Français (France) 
English (United Kingdom) 
