COMVOI (2019-2022)
« Role of intercellular communication in the adaptation of bronchial tumor cells with impaired RASSF1A/Hippo pathway to their microenvironment »
Methylation of the RASSF1 tumor suppressor gene promoter predicts poorer survival in patients with non-small cell lung cancer (NSCLC). We have shown that this worse prognosis is explained by the fact that the inactivation of RASSF1A deregulates the Hippo and Rho-GTPase signaling pathways, thus promoting the metastatic phenotype of tumor cells and their communication via long cytoplasmic extensions, called tunneling nanotubes (TNTs). This project focuses on the place of TNTs and more broadly of intercellular communication in the adaptation of bronchial tumor cells presenting an alteration of the RASSF1A/Hippo pathway to their microenvironment.
Partners : ISTCT (Caen), CMABio3/ICORE (Caen), SEBIO (Havre, FR)
Français (France) 
English (United Kingdom) 
